There are 124 cities with a population over 200,000 in the U.S. According to the U.S. Census Bureau's population estimates for last year, over 90% of the U.S. population growth last year took place outside of its 124 largest cities. About a third of those cities lost population last year. The total growth in the population of cities with over 200,000 residents grew by .23%, less than half of what the U.S. grew last year.